https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Monitoring patient response to pembrolizumab with peripheral blood exhaustion marker profiles https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44986 Wed 26 Oct 2022 15:06:56 AEDT ]]> Low tumour-infiltrating lymphocyte density in primary and recurrent glioblastoma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48900 Wed 19 Apr 2023 16:40:13 AEST ]]> Nucleotide excision repair protein ERCC1 and tumour-infiltrating lymphocytes are potential biomarkers of neoadjuvant platinum resistance in high grade serous ovarian cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35727 Wed 14 Jun 2023 12:38:16 AEST ]]> Regulators of global genome repair do not respond to DNA damaging therapy but correlate with survival in melanoma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14356 Wed 11 Apr 2018 15:41:30 AEST ]]> Repair of UVB-induced DNA damage is reduced in melanoma due to low XPC and global genome repair https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27853 T transitions. These mutations are found throughout the melanoma genome, particularly in non-transcribed regions. The global genome repair (GGR) branch of nucleotide excision repair (NER) is responsible for repairing UV-induced DNA damage across non-transcribed and silent regions of the genome. This study aimed to examine the relationship between UVB and GGR in melanoma. DNA repair capacity and relative expression of NER in melanocytes and melanoma cell lines before and after treatment with UVB was quantified. Transcript expression from 196 melanomas was compared to clinical parameters including solar elastosis and whole transcriptome data collected. Melanoma cell lines showed significantly reduced DNA repair when compared to melanocytes, most significantly in the S phase of the cell cycle. Expression of GGR components XPC, DDB1 and DDB2 was significantly lower in melanoma after UVB. In the melanoma tumours, XPC expression correlated with age of diagnosis and low XPC conferred significantly poorer survival. The same trend was seen in the TCGA melanoma dataset. Reduced GGR in melanoma may contribute to the UV mutation spectrum of the melanoma genome and adds further to the growing evidence of the link between UV, NER and melanoma.]]> Wed 02 Mar 2022 14:27:55 AEDT ]]> Confocal microscopy, dermoscopy, and histopathology features of atypical intraepidermal melanocytic proliferations associated with evolution to melanoma in situ https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44783 Tue 30 Apr 2024 09:05:42 AEST ]]> The regenerating naevus https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29180 Thu 24 Mar 2022 11:30:18 AEDT ]]> Repurposing azacitidine and carboplatin to prime immune checkpoint blockade-resistant melanoma for anti-PD-L1 re-challenge https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49310 Thu 11 May 2023 14:39:28 AEST ]]> BRAF mutation testing for patients diagnosed with stage III or stage IV melanoma: practical guidance for the Australian setting https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47367 Fri 13 Jan 2023 14:57:43 AEDT ]]>